Friday, July 27, 2012

The Recombinant Combatant

In speaking of different injectable insulins, I mentioned "recombinant" DNA, usually put in insulin terms as rDNA. Eli Lilly and Company speaks of "rDNA origin" or "rDNA (human) insulin." Trying to keep the blog post to "blog friendly" word limits prevented a more basic and user friendly definition at the time.
Different sites define "recombinant DNA" as "combined DNA," "artificial DNA," "technological DNA," and "genetically modified DNA." In my quick research, I encountered only insulin manufacturers indicating that "recombinant" meant "human." Their wording is cautious, not stating "human" is the definition of "recombinant" but misleading people into assuming that definition by context.
Basically and keeping to insulin applications, "recombinant technology" is a scientific process where different strands of DNA are combined to create or isolate the specific biochemicals needed, in this case the insulin hormone. Yes, this is a cloning process, not of entire bodies but of specific cells. I don’t know that the pharmaceutical companies are constantly combining DNA strands for new batches of insulin. I assume they clone the insulin cells on a massive scale to produce those tiny vials for more than $50.00 each.
"Cloning" is a loaded word. There is the risk of "moral" outrage by people who envision that the process involves the cloning of entire people, the removal of the insulin from their bodies, then disposal of the bodies as by-products used in cat food or something. I was a kid at the time, but remember newscasts reporting the first test tube" baby and the moral opposition some people had to the process. As an adult, I have seen (back when I could see) noses wrinkle in disdain and disapproval when a pregnant woman who candidly admitted to getting knocked up "in vitro" left the room.
Experiences like that give me some understanding of why the pharmaceuticals might mislead potential consumers and the users of their products about the true origins of "human origin" insulin. The nut jobs who would find cloned insulin as some kind of abomination do exist. The rDNA based insulin hit the market in the 1980’s, yet the pharmaceuticals continue to mislead about the definition of "recombinant" as if the word itself means "human." They went so far as to dub their patented formula "Humulin."
So what else might those same companies mislead the public about?

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